Hello, I just recently increased my Zoloft to 150 mg since it wasnt working too much before. Has anyone here taken Zoloft and only had it work successfully when it was at a high dosage, like 150-200mg? I was on 250 mg up until about two months ago, and it still didn't help! 300 is the max that you can go on safely, and it was just useless to bump me up another 50 mg because it wouldn't have done much good. Anyway, yes, that is a fairly high dosage, but anxiety disorders (especially panic attacks/disorder and OCD- I have both panic attacks and OCD) often require a higher dosage to treat than depression. Usually, the SSRI isn't enough, and a benzodiazepine like Valium, Xanax, or Klonopin (what I'm on) needs to be added. -Gatsby Luvr1920- Thanks for getting back with me Gatsby. I have heard that Paxil may be the best for anxiety but it also has a lot of weight gain issues...I will try to do this increase and hope it works! Dragonflyzz- I started Zoloft, 25 mg, in the spring of sophomore year, at age 15, before I knew what was wrong with me. The doctor said that it sounded like "Generalized Anxiety Disorder" (which, I do have, but it's so intertwined with my OCD, that it barely shows), and that the Zoloft would help. impotence There's many negative stories out there about Zoloft, so I'm wondering if anyone can share a positive experience from taking it. I was on it many years ago, but don't remember the start up effects, how long it took to work, etc. The time has come to use this medication again, but my anxiety is so bad that I'm afraid to take it. I do use Xanax, but I can no longer pretend that that's enough to help me. There's a lot of depression involved as well, so my back is against the wall. Metformin cancer prevention Any positive experiences of Zoloft controlling anxiety & depression? Follow Posted 21 months ago, 8 users are following. Psyched_Out_Kim. All the best. 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The healthcare provider may choose to increase the sertraline dosage if symptoms continue, or decrease the dose if side effects occur. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click In order for us to create your customized Health Savvy programs, we need a little more information about the health topic(s) that you are interested in. There are 11 references cited in this article, which can be found at the bottom of the page. She received her Associates Degree in Nursing from Olney Central College in 1987. Calibrating Your Dosage Taking Zoloft Safely Combining Zoloft with Other Medical Therapies Community Q&A11 References When used properly, Zoloft can greatly improve the quality of life for people suffering from depression, anxiety, panic disorders, and other conditions. 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