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    Accepted for publication 17 February 2017 Published Volume 20 Pages 1481—1488 DOI https://doi.org/10.2147/DDDT. S131670 Checked for plagiarism Yes Review by Single-blind Peer reviewers approved by Dr Rasika Samarasinghe Peer reviewer comments 2 Editor who approved publication: Professor Manfred Ogris Ph D School in Experimental Medicine, University of Pavia, Pavia, Italy Purpose: The purpose of this study is to evaluate, in a randomized clinical trial, the effects of metformin immediate release (IR) compared with metformin extended release (XR) on the gastrointestinal tolerability and glycemic control. Materials and methods: We enrolled 253 Caucasian patients with type 2 diabetes not well controlled by diet (glycated hemoglobin [Hb A, fasting and postprandial glucose, fasting plasma insulin (FPI) and homeostasis model assessment insulin resistance (HOMA-IR), lipid profile, and levels of some adipocytokines, including tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), visfatin, and vaspin. Moreover, at the baseline and after 6 months, we administered patients some validated questionnaires to assess patients’ satisfaction toward treatments. Results: After 6 months, both formulations gave a similar reduction in body weight and body mass index (BMI); however, metformin XR gave a greater improvement in glycemic control, FPI, and HOMA-IR, compared with both baseline and metformin IR. A reduction in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol was observed with metformin XR compared with IR. Levels of TNF-α, hs-CRP, and vaspin were reduced by metformin XR but not by the IR formulation. Conclusion: Metformin XR formulation seems to be more effective than metformin IR in improving glyco-metabolic control, lipid profile, and levels of some adipocytokines in patients with type 2 diabetes mellitus. Glucophage SR 500mg, 750mg and 1000mg prolonged release. what store can i buy doxycycline Metformin medicine to treat type 2 diabetes - NHS. UK Metformin - Wikipedia
     
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