Prednisolone acetate ophthalmic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile ophthalmic suspension and used to reduce swelling, redness, itching, and allergic reactions affecting the eye. Although there are no major human studies of prednisolone use in pregnant women, studies in several animals show that it may cause birth defects including increase cleft palate. Prednisolone should be used in pregnant women when benefits outweigh the risks and children born from mothers using prednisolone during pregnancy should be monitored for impaired adrenal function. Prednisolone is found in breast milk of mothers taking prednisolone. As a glucocorticoid, the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes. metformin function Since we published our article on “turmeric for dog arthritis” (read here) we have been flooded with queries on how much turmeric one should give to dogs and how. So here is a short article on turmeric dosage for dogs. I have structured this article based on common questions asked regarding turmeric dosage for dogs. Here is the dosage as recommended by Karen Rosenfeld. Karen has been involved with dogs and cats for over 30 years and has developed this table based on her experience. Give just 1/3rd of the max quantity or even less to start with. If all goes well for a few days increase the dosage. If you need a hand in identifying a good brand, here is our list of recommended brands. But yes, one can change the dosage a bit based on the severity of the problem. Well if we go by how humans are advised to take turmeric – it should not. For example, if you are giving turmeric to your perfectly health dog, the below mentioned dosage works very well. But, for example if your dog is in severe pain a high dosage for a few days is also fine. We do follow and recommend a weight based turmeric dosage. 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If it is hard to get your dog to take a pill, the antibiotic baytril is available in a tasty chewable tablet. However, as with all chewable pet meds you will want to be careful and keep the medication out of your pet's reach so they do not accidentally overdose on the product. There are also some liquid drop variety antibiotics that are popular for cats, but many, including cefa drops, amoxi drops, antirobe liquid, albon suspension and others can be given to dogs too. Your dog's veterinarian should know what antibiotic will work best for your dog's specific requirements. Quinolone antibiotics (including ciprofloxacin) may cause serious and possibly permanent tendon damage (such as tendonitis, tendon rupture), nerve problems in the arms and legs (peripheral neuropathy), and nervous system problems. Get medical help right away if you have any of the following symptoms: pain/numbness/burning/tingling/weakness in your arms/hands/legs/feet, changes in how you sense touch/pain/temperature/vibration/body position, severe/lasting headache, vision changes, shaking (tremors), seizures, mental/mood changes (such as agitation, anxiety, confusion, hallucinations, depression, rare thoughts of suicide). Tendon damage may occur during or after treatment with this medication. Stop exercising, rest, and get medical help right away if you develop joint/muscle/tendon pain or swelling. Your risk for tendon problems is greater if you are over 60 years of age, if you are taking corticosteroids (such as prednisone), or if you have a kidney, heart, or lung transplant. This medication may make a certain muscle condition (myasthenia gravis) worse. Tell your doctor right away if you have new or worsening muscle weakness (such as drooping eyelids, unsteady walk) or trouble breathing. 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A comprehensive section on antibiotics for dogs, cats, birds and fish including medication profiles and sources for low discount prices online.