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    Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill. Get Started Comment: I suffer from osteoarthritis and major depressive disorder. Show Full Comment Comment: I suffer from osteoarthritis and major depressive disorder. After 11years on paxil, and having read the possible benefit of pain reduction, I asked doctor about changing. After 11years on paxil, and having read the possible benefit of pain reduction, I asked doctor about changing. I don't think there is any difference in pain control, but I hate to think how bad it would be without it. I stepped down from Paxil, while starting duloxetine on small dose then increasing as Paxil was phased out. I stepped down from Paxil, while starting duloxetine on small dose then increasing as Paxil was phased out. I believe my body had become immune to or adjusted to the Paxil so much that it was no longer effective. Other than some sweating at night, I have no side effects. I am a content person now and no longer dread social situations. prednisone 20 mg cost This is not a list of all drugs or health problems that interact with duloxetine. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take duloxetine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. However, many people have no side effects or only have minor side effects.

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    Take this medicine only as directed by your doctor to benefit your condition as much as possible. You will need to use this medicine for several weeks before you begin to feel better. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Keep using the medicine even if you feel you are not getting better, and talk to your doctor if you have any questions. Swallow the delayed-release capsule whole with or without food. Do not open the capsule and sprinkle the contents on food or in liquids. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. It thus did not recommend duloxetine as a first line treatment for major depressive disorder, given the (then) high cost of duloxetine compared to inexpensive off-patent antidepressants and lack of increased efficacy. do not list duloxetine among the recommended treatment options. A review from the Annals of Internal Medicine lists duloxetine among the first line drug treatments, however, along with citalopram, escitalopram, sertraline, paroxetine, and venlafaxine.

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