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    For adult patients with type 2 diabetes mellitus: Janumet is indicated as an adjunct to diet and exercise to improve glycaemic control in patients inadequately controlled on their maximal tolerated dose of metformin alone or those already being treated with the combination of sitagliptin and metformin. Janumet is indicated in combination with a sulphonylurea (i.e., triple combination therapy) as an adjunct to diet and exercise in patients inadequately controlled on their maximal tolerated dose of metformin and a sulphonylurea. Janumet is indicated as triple combination therapy with a peroxisome proliferator-activated receptor gamma (PPARγ) agonist (i.e., a thiazolidinedione) as an adjunct to diet and exercise in patients inadequately controlled on their maximal tolerated dose of metformin and a PPARγ agonist. Janumet is also indicated as add-on to insulin (i.e., triple combination therapy) as an adjunct to diet and exercise to improve glycaemic control in patients when stable dose of insulin and metformin alone do not provide adequate glycaemic control. The dose of antihyperglycaemic therapy with Janumet should be individualised on the basis of the patient's current regimen, effectiveness, and tolerability while not exceeding the maximum recommended daily dose of 100 mg sitagliptin. Adults with normal renal function (GFR ≥ 90 m L/min) For patients not adequately controlled on metformin alone, the usual starting dose should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) plus the dose of metformin already being taken. The dose should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) and a dose of metformin similar to the dose already being taken. Glucophage 500 mg: One film-coated tablet contains 500 mg metformin hydrochloride corresponding to 390 mg metformin base. Glucophage 500 mg: White, circular, convex film-coated tablets 11 mm in diameter and 5.7 mm high, engraved with GL 500. Glucophage 850 mg: One film-coated tablet contains 850 mg metformin hydrochloride corresponding to 662.9 mg metformin base. Glucophage 850 mg: White, circular, convex film-coated tablets 13.5 mm in diameter and 6.6 mm high, engraved with GL 850. Treatment of type 2 diabetes mellitus, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control. • In adults, Glucophage may be used as monotherapy or in combination with other oral antidiabetic agents or with insulin. • In children from 10 years of age and adolescents, Glucophage may be used as monotherapy or in combination with insulin. A reduction of diabetic complications has been shown in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failure (see section 5.1). Adults with normal renal function (GFR≥ 90 m L/min) Monotherapy and combination with other oral antidiabetic agents The usual starting dose is 500 mg or 850 mg metformin hydrochloride 2 or 3 times daily given during or after meals.

    Metformin spc

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  7. For adult patients with type 2 diabetes mellitus Janumet is indicated as an adjunct to diet and exercise to improve glycaemic control in patients inadequately controlled on their maximal tolerated dose of metformin alone or those already being treated with the combination of sitagliptin and metformin.

    • Janumet 50 mg/1000 mg film-coated tablets -
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    • Jentadueto, INN-linagliptin/metformin HCl - European Medicines Agency

    Metformin exerts its effect mainly by decreasing gluconeogenesis and by increasing peripheral utilisation of glucose; since it acts only in the presence of. phone number to order cialis This study will assess the efficacy of vildagliptin plus metformin SPC treatment in type 2 diabetes mellitus patients uncontrolled by metformin monotherapy after. This page shows the Summary of Product Characteristics SPC and patient. To view details for METFORMIN 500MG TABLETS, please read and accept the.

     
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