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    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Clomiphene, an oral FDA-approved agent for female infertility has been shown to normalize testosterone levels in men with hypogonadotropic hypogonadism. This study will compare testosterone responses to clomiphene citrate in male veterans with hypothalamic hypogonadism naïve to treatment with responses of similar patients already receiving treatment with injectable or transdermal testosterone. Listing a study does not mean it has been evaluated by the U. This is an open-label, prospective, interventional trial to be conducted in an outpatient specialty care setting. This study aims to explore whether men with low testosterone levels, due to altered brain regulation of male hormone function, who have been previously treated with testosterone, respond as well as men who have not been so treated to clomiphene citrate, an agent commonly used for female infertility that has been shown to improve male hormone secretion in some cases. We will randomize 64 hypogonadal male veterans evenly divided between naive and previous treatment and treat for 8 weeks with clomid, increasing the initial dose of 25 mg to 50 mg/day in those who fail to achieve target testosterone level (450 ng/dl) after the first 3 weeks. Endpoint measurements performed in the Phoenix VA Health Care System (PVAHCS) clinical laboratory will be total testosterone as well as bioavailable testosterone and sex hormone binding globulin. Total testosterone level at 8 weeks of treatment will be reported as the primary endpoint. Clomiphene citrate and testosterone gel replacement therapy for male hypogonadism: efficacy and treatment cost. Safety measures (CBC,liver functions, PSA) will be assessed at 8 weeks as well. Clomid for Men with Low Testosterone Part One by Jeffrey Dach MD amoxicillin dosage Overview of Clomid Infertility Treatment for Men - Verywell Family Clomiphene Citrate CC or Clomid – A
     
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