TORONTO -- The recall earlier this week of a batch of Alesse birth control pills sold past their expiry date has raised questions about whether it's safe to take over-the-counter and prescription medications beyond their best-before marker -- and just how long past? "I think it would alarm a lot of Canadians if they knew that there isn't a lot of study on this," said Phil Emberley, director of pharmacy innovation at the Canadian Pharmacists Association. Drug manufacturers must provide evidence on the potency and safety of products related to exposure to light, heat and humidity in order to get market approval from Health Canada, using what are known as stability studies. "The purpose of the stability study is to establish, based on testing a minimum of three batches of the drug product, a shelf life and label storage instructions applicable to all future batches of the drug product manufactured and packaged under similar circumstances," Health Canada says. These tests include studies in which pilot batches of medications are stored at a temperature of about 25 C, with about 60 per cent relative humidity, for a minimum of 12 months, the federal department says on its website. The expiration date is the final date that a manufacturer will guarantee 100 per cent potency and safety of a medication, based on stability testing under Health Canada's good manufacturing practices, or GMP. But that best-before date is based on an unopened container. clonidine and menopause If you are looking for brand-name Valtrex online, manufactured by Glaxo Smith Kline, I recommend Access S.-licensed physicians and pharmacists who are available to answer your medical questions. They have been in business since 1998, they are located in Tempe, Arizona, and you can receive overnight shipping if you order by 4 p.m. Access provides excellent customer service, and they are available to take your calls Monday through Saturday. 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Common adverse drug reactions (≥1% of patients) associated with valaciclovir therapy are the same as for aciclovir, its active metabolite, and include: nausea, vomiting, diarrhea and headache. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, edema, arthralgia, sore throat, constipation, abdominal pain, rash, weakness and/or renal impairment. Rare adverse effects ( Valaciclovir belongs to a family of molecules first described and patented by Paolo Cornaglia Ferraris in 1982 (patents EP0077460 A2, CA1258149A1, DE3273785D1, EP0077460A3, EP0077460B1, US4567182). Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism. HSV and VZV infections are opportunistic infections (OIs) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. Off-label use, for example, can include using a drug for a different disease or medical condition. Good medical practice and the best interests of a patient sometimes require that a medicine be used off-label. The guidelines include recommendations on the following uses of valacyclovir hydrochloride: On-label uses: The above list may not include all of the HIV-related uses of valacyclovir hydrochloride recommended in the guidelines. Some recommended uses, such as uses in certain rare circumstances, may have been omitted. Take valacyclovir hydrochloride according to your health care provider’s instructions. Your health care provider will tell you how much valacyclovir hydrochloride to take and when to take it. 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