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    This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. 4, 2009 -- Men suffering penis pain and damage from erections lasting longer than four hours may benefit from an orphan drug used to treat severe "bubble boy" immune deficiency, mouse studies suggest. The condition, called priapism, seems funny only to those who have never suffered it. Erections lasting longer than four hours cut off the supply of fresh blood to the penis. While studying mice missing the gene that malfunctions in kids with severe combined immune deficiency (SCID), Yang Xia, MD, Ph D, and colleagues at the University of Texas, Houston, noticed that the mice suffered priapism and penile fibrosis. More than 40% of men with sickle-cell anemia suffer priapism. The result: Penile fibrosis, the formation of scar tissue in the main body of the penis. Replacing the enzyme made by the gene -- adenosine deaminase -- not only relieved priapism, but markedly reduced the animals' penile fibrosis. It also strikes some men with diabetes and can be a side effect of erectile dysfunction drugs -- particularly those injected into the penis. "We identified a new application to treat priapism with a drug that is commonly used to treat SCID," Xia tells Web MD. "When we treated the mice, we do not see any side effects or any abnormality. We can quickly correct the priapism and prevent and treat penile fibrosis." Current treatments for priapism are not optimal, says Harinder Juneja, MD, a University of Texas hematologist who treats many patients with sickle-cell disease. If drug injections can't tighten the muscle that controls blood flow to the penis, the excess blood must be withdrawn from the main body of the penis. Sildenafil is a common medication used to stimulate erections in men with erectile dysfunction (ED) and treat certain heart conditions. Many factors can influence how long Viagra takes to start working. In general, Viagra takes about 30 minutes to produce noticeable effects. But your diet, your overall health, the medications you’re taking, underlying conditions, and much more can all affect the amount of time Viagra takes to work in your body and how long it lasts. An erection happens when nerves in your penis are stimulated. Then, muscles around two cylinder-shaped chambers of spongy material along your penis, known as the corpus cavernosa, relax and allow blood to flow in, causing an erection. With ED, your nerves don’t communicate properly with your brain and blood doesn’t flow properly into the corpus cavernosa. Taking Viagra relaxes the walls of your blood vessels and lets blood flow more easily into the parts of your penis that cause an erection. You’ll still need to feel sexually aroused to get an erection.

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