Consumer Medicine Information This leaflet answers some common questions about Zoloft. It does not take the place of talking to your doctor or pharmacist. Your doctor has weighed the risks of you taking Zoloft against the benefits it is expected to have for you. Zoloft is used to treat depression and conditions called obsessive compulsive disorder (OCD), panic disorder, social phobia (social anxiety disorder) and premenstrual dysphoric disorder (PMDD). If you have any concerns about taking this medicine, ask your doctor or pharmacist. PMDD affects some women in the days before their period. PMDD is different from premenstrual syndrome (PMS). The mood symptoms (anger, sadness, tension, etc) in PMDD are more severe than in PMS and affect the woman's daily activities and relationships with others. Zoloft belongs to a group of medicines called selective serotonin reuptake inhibitors (SSRIs). 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